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Decreased activity of GPX4 prevents the metabolism of lipid peroxides via GPX4-catalyzed glutathione (GSH) reduction reactions, resulting in the oxidation of divalent iron ions and the generation of reactive oxygen species (ROS) in lipids (19)

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K., Khogali, M

However, pretty much every facet of modern-day life can contribute to draining our glutathione levels

32 GST in regulation of MAPK pathway Besides metabolite detoxification, GST also exhibits ligand-binding properties that allow the enzyme to interact covalently and noncovalently with compounds, resulting in inhibition of conjugation activity